BDBM50017452 2-chloro-6-piperazin-1-ylpyrazine::6'-Chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl::6'-Chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl(MK-212)::CHEMBL269521::L-630,571::MK 212::MK-212

SMILES Clc1cncc(n1)N1CCNCC1

InChI Key InChIKey=CJAWPFJGFFNXQI-UHFFFAOYSA-N

Data  31 KI  4 EC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50017452   

Target5-hydroxytryptamine receptor 3A(RAT)
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  29nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  97.7nMMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(NEONATAL RAT)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  125nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2C adrenergic receptor(OK)
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  126nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Albany Medical College

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Albany Medical College

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  151nMMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
University of Nebraska

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  153nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  178nMAssay Description:Binding affinity at rat 5-hydroxytryptamine 1B receptor by [3H]-5-HT displacement.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  202nMAssay Description:Binding affinity at rat 5-hydroxytryptamine 1A receptor by [3H]-WB-4101 displacement.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  214nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Albany Medical College

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  255nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  295nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Albany Medical College

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  339nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(RAT)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  407nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Institut de Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  617nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A/1B/1D/1F(RAT)
McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  844nMAssay Description:Binding affinity determined in radioreceptor binding assay by using [3H]5-HT radioligand against 5-hydroxytryptamine 1 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  891nMMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  913nMAssay Description:Binding affinity against rat Alpha-1 adrenergic receptor.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A/2B/2C(Rattus norvegicus (rat))
McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity at rat 5-hydroxytryptamine 2 receptor by [3H]ketanserin displacement.More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against rat Dopamine receptor D2.More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(RAT)
McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity at rat Dopamine receptor D1 by [3H]-SCH-23,390 displacement.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  1.02E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Albany Medical College

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  2.55E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Albany Medical College

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  2.55E+3nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  3.40E+3nMAssay Description:Displacement of [3H]mesulergine from human 5HT2C receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  3.63E+3nMAssay Description:Intrinsic affinity of the compound towards serotonin receptor from rat frontal cortex by displacement of [3H]-5-HTMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  6.00E+3nMAssay Description:Intrinsic affinity of the compound towards serotonin receptor from rat frontal cortex by displacement of [3H]-spiperone.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(RAT)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataKi:  2.10E+4nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in tsA201 cell membranes after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataEC50:  160nMAssay Description:Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as accumulation of IP1 incubated for 1 hr at 37 degC followed by 15 mins ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataEC50:  420nMAssay Description:Agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by flu...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50017452(2-chloro-6-piperazin-1-ylpyrazine | 6'-Chloro-3,4,...)
Show SMILES Clc1cncc(n1)N1CCNCC1
Show InChI InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
Affinity DataEC50:  28nMAssay Description:Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as induction of intracellular calcium release measured for 90 secs by flu...More data for this Ligand-Target Pair