BDBM50018518 ((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphthalen-1-ylmethyl-amine::(6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphthalen-1-ylmethyl-amine::(6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphthalen-1-ylmethyl-amine(Terbinafine)::(E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine::1N,6,6-trimethyl-1N-(1-naphthylmethyl)-(E)-2-hepten-4-yn-1-amine::CHEMBL822::Lamisil::Lamisil at::N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine::N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine::SF-86-327::TERBINAFINE::Terbinafin::Terbinafine Hydrochloride::cid_1549008

SMILES CN(C\C=C\C#CC(C)(C)C)Cc1cccc2ccccc12

InChI Key InChIKey=DOMXUEMWDBAQBQ-WEVVVXLNSA-N

Data  3 KI  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50018518   

TargetSqualene monooxygenase(Homo sapiens (Human))
State University of New York

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataKi:  30nMAssay Description:Apparent inhibitory constant of the compound against squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetC-8 sterol isomerase ERG2(Saccharomyces cerevisiae)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataKi: >5.00E+4nMAssay Description:Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataKi: >5.00E+4nMAssay Description:Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Rattus norvegicus)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataIC50:  9.30E+4nMAssay Description:Inhibitory activity against rat liver Squalene EpoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataIC50: >2.50E+4nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University of New York

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory activity against guinea pig Squalene EpoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute

Curated by PubChem BioAssay
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataEC50: >5.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay