BDBM50018816 CHEMBL3286808

SMILES COc1ccc(F)cc1[C@@H](C)Oc1cc(cnc1N)-c1cnnn1C

InChI Key InChIKey=GXUFIECYEKHMLD-SNVBAGLBSA-N

Data  2 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50018816   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018816(CHEMBL3286808)
Affinity DataKi:  4nMAssay Description:Inhibition of wild type human recombinant ALK kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-CONH...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018816(CHEMBL3286808)
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant ALK L1196M mutant kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018816(CHEMBL3286808)
Affinity DataIC50:  95nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018816(CHEMBL3286808)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair