BDBM50018822 CHEMBL3286812
SMILES CNC(=O)c1ccc(F)cc1[C@@H](C)Oc1nc(cnc1N)-c1cccnc1OC
InChI Key InChIKey=AMLQLZSHSQNJKQ-LLVKDONJSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50018822
Affinity DataKi: 0.850nMAssay Description:Inhibition of wild type human recombinant ALK kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-CONH...More data for this Ligand-Target Pair
Affinity DataKi: 8.20nMAssay Description:Inhibition of human recombinant ALK L1196M mutant kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 312nMAssay Description:Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair