BDBM50019057 (+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol::4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol::4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol(6-FEPI)::CHEMBL42359

SMILES CNCC(O)c1cc(O)c(O)cc1F

InChI Key InChIKey=DKBXREAGJFVVAP-UHFFFAOYSA-N

Data  7 KI  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50019057   

TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  9nMAssay Description:Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  700nMAssay Description:Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  700nMAssay Description:Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Canis familiaris)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  5.00E+4nMAssay Description:Binding of [3H]-dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(GUINEA PIG)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  6.30E+4nMAssay Description:Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  6.30E+4nMAssay Description:Displacement of [3H]dihydroalprenolol from adrenergic beta 1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50:  100nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(GUINEA PIG)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50: >1.50E+3nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50: >1.50E+3nMAssay Description:Agonistic potency at beta adrenergic receptor for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50: >1.50E+3nMAssay Description:Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50:  800nMAssay Description:Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed