BDBM50019059 (+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol::3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol::3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol(2-FEPI)::CHEMBL43711

SMILES CNCC(O)c1ccc(O)c(O)c1F

InChI Key InChIKey=HGZKLMFEVVYGMO-UHFFFAOYSA-N

Data  8 KI  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50019059   

TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  66nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Canis familiaris)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  260nMAssay Description:Binding of [3H]-dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  1.80E+3nMAssay Description:Binding of [3H]-dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [3H]dihydroalprenolol from adrenergic beta 1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(GUINEA PIG)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenololMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  1.65E+4nMAssay Description:Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  1.65E+4nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50:  40nMAssay Description:Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(GUINEA PIG)
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50:  40nMAssay Description:Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50:  40nMAssay Description:Agonistic potency at beta adrenergic receptor for the stimulation of accumulation of cyclic AMP in cultured C6 glioma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonistic potency at alpha 2-Adrenergic receptor for inhibition of 10 uM forskolin-elicited stimulation of adenylate cyclase in human platelet membra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50019059((+/-)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed