BDBM50019355 1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline-6,7-diol::1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol::CHEMBL299175::R(+)-TMQ::TMQ, Racemic::Tretoquinol

SMILES COc1cc(CC2NCCc3cc(O)c(O)cc23)cc(OC)c1OC

InChI Key InChIKey=RGVPOXRFEPSFGH-UHFFFAOYSA-N

Data  18 KI  4 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50019355   

TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  10.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  20.9nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  22.9nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  44nMAssay Description:Binding affinity for human Beta-2 adrenergic receptor expressed in CHO cells by radioligand competition binding assays using [125I]iodocyanopindolol ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  44nMAssay Description:Binding Affinity against human beta-2 adrenergic receptor expressed in Chinese hamster ovary(CHO) cells was measured by using [125I]ICYP radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  45.7nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  49nMAssay Description:Binding affinity against Beta-2 adrenergic receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  87nMAssay Description:Binding affinity against Beta-1 adrenergic receptor in guinea pig left ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  87.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  100nMAssay Description:Inhibition of [3H]dihydroalprenolol binding to Beta adrenergic receptor from rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  105nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  162nMAssay Description:Binding affinity for human Platelet Thromboxane A2 / Prostaglandin (TP), by radioligand competition binding assays using [3H]-SQ 29548 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  324nMAssay Description:Binding affinity for human Beta-1 adrenergic receptor expressed in CHO cells by radioligand competition binding assays using [125I]iodocyanopindolol ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  324nMAssay Description:Binding Affinity against human Beta-1 adrenergic receptor expressed in Chinese hamster ovary(CHO) cells was measured by using [125I]ICYP radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
University Of Tennessee

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  3.72E+3nMAssay Description:Binding Affinity against human Beta-3 adrenergic receptor expressed in Chinese hamster ovary(CHO) cells was measured by using [125I]ICYP radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of [3H]spiroperidol binding to dopamine receptor from rat striatum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(MOUSE)
University Of Edinburgh

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha adrenergic receptor from rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataEC50:  31nMAssay Description:Compound was tested for its intrinsic activity against beta adrenergic receptor of isolated guinea pig atrial pairsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataIC50:  6.10nMAssay Description:Compound was evaluated for its inhibitory activity against CHO cells expressing the cloned human beta2 adrenergic receptor (AR) in the presence of [1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataEC50:  14nMAssay Description:Compound was evaluated for its inhibitory activity against human Beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataEC50:  3.5nMAssay Description:Compound was evaluated for its inhibitory activity against human beta2 adrenergic receptor (AR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataIC50:  6.10nMAssay Description:Compound was evaluated for its inhibitory activity against human beta1 adrenergic receptor (AR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataEC50:  174nMAssay Description:Inhibitory activity against Beta-1 adrenergic receptor in guinea pig atria after treatment with the compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataIC50:  282nMAssay Description:Inhibitory activity against U-46,619-induced responses in human platelet aggregation (Thromboxane A2 alpha receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
University Of Tennessee-Memphis

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataIC50:  447nMAssay Description:Inhibitory concentration against radioligand [3H]SQ-29,548 (5 nM) binding to TP receptors in human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Ohio State University

Curated by PDSP Ki Database
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataEC50:  26nMAssay Description:Inhibitory activity against Beta-2 adrenergic receptor in guinea pig trachea after treatment with the compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
University Of Tennessee

Curated by ChEMBL
LigandPNGBDBM50019355(1-(3,4,5-Trimethoxy-benzyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataEC50:  1.70nMAssay Description:Inhibitory activity against human beta3 adrenergic receptor (AR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed