BDBM50019646 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline::2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole::CHEMBL17860::lofexidine

SMILES CC(Oc1c(Cl)cccc1Cl)C1=NCCN1

InChI Key InChIKey=KSMAGQUYOIHWFS-UHFFFAOYSA-N

Data  5 KI  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50019646   

TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataKi:  4.40nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNischarin(RAT)
University Of Belgrade

Curated by ChEMBL
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2B expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataKi:  69nMAssay Description:Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataIC50:  43nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2-adrenoceptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataIC50:  7.30nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2 adrenergic receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataIC50:  43nMAssay Description:Compound was tested for its ability to inhibit specific binding of [3H]clonidine to alpha-2-adrenoceptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataIC50:  660nMAssay Description:Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.2 nM) to rat isolated brain membr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataEC50:  126nMAssay Description:Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed