BDBM112777 NORTRIPTYLINE::US8629135, SW-02

SMILES [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12

InChI Key InChIKey=PHVGLTMQBUFIQQ-UHFFFAOYSA-N

Data  44 KI  26 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 70 hits for monomerid = 112777   

TargetNorepinephrine transporter(Rat)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  0.990nMMore data for this Ligand-Target Pair

Target InfoUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  1.49nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  4.37nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

Target5-hydroxytryptamine receptor 2A(Rat)
University of Turku

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  5nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  6.30nMAssay Description:Compound was evaluated for its binding affinity towards human NET (norepinephrine) transporterMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  8.30nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHistamine H1 receptor(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  8.40nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

Target5-hydroxytryptamine receptor 2C(Rat)
University of Turku

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  8.5nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  15nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  18nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  18nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent noradrenaline transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  21nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetNorepinephrine transporter(Rat)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  25nMMore data for this Ligand-Target Pair

Target InfoUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  37nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M1(Human)
Mayo Foundation

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  40nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  41nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHistamine H1 receptor(Rat)
TBA

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  46nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M3(Human)
Mayo Foundation

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  50nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetAlpha-1A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  55nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  60nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  60.8nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  60.8nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M4(Human)
Mayo Foundation

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  84nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M5(Human)
Mayo Foundation

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  97nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M2(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  110nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

Target5-hydroxytryptamine receptor 6(Rat)
University of Alberta

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  148nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

Target5-hydroxytryptamine receptor 6(Rat)
University of Alberta

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  148nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  197nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

Target5-hydroxytryptamine receptor 6(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  214nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  279nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

Target5-hydroxytryptamine receptor 1A(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  294nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  317nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent dopamine transporter(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  1.14E+3nMMore data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent dopamine transporter(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  1.20E+3nMMore data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent serotonin transporter(Rat)
Emory University

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  1.70E+3nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
TBA

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetAlpha-2A adrenergic receptor(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  2.03E+3nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetD(2) dopamine receptor(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  2.57E+3nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetSodium-dependent dopamine transporter(Human)
Mayo Clinic

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  5.00E+3nMMore data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetBeta-2 adrenergic receptor(Human)
TBA

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetSodium-dependent dopamine transporter(Rat)
Pfizer

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails PubMed
Copy BDB DOI

TargetCytochrome P450 2C8(Human)
F. Hoffmann-La Roche

Curated by ChEMBL

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataKi:  4.99E+4nMAssay Description:Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using a recombinant systemMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetHistamine H1 receptor(Rat)
TBA

Curated by PDSP K_i Database

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataIC50:  0.0500nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCytochrome P450 2D26(Rat)
Vrije Universiteit

Curated by ChEMBL

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCytochrome P450 2D6(Human)
Vrije Universiteit

Curated by ChEMBL

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell lineMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCytochrome P450 2D3(Rat)
Vrije Universiteit

Curated by ChEMBL

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataIC50:  1.42E+4nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D3 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
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TargetCytochrome P450 2D1(Rat)
Vrije Universiteit

Curated by ChEMBL

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataIC50:  2.04E+5nMAssay Description:Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D1 expressed in Saccharomyces cerevisiaeMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCytochrome P450 2D6(Human)
Vrije Universiteit

Curated by ChEMBL

LigandBDBM112777(NORTRIPTYLINE | US8629135, SW-02)Copy SMILESCopy InChI

Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory concentration against cytochrome P450 2D6More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseMCE
KEGGPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI