BDBM50020930 CHEMBL3287293

SMILES OC(=O)c1csc(n1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1

InChI Key InChIKey=PHCCZZHEZZPUGG-UHFFFAOYSA-N

Data  1 KI  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50020930   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataKi:  65nMAssay Description:Inhibition of F-Bak (GQVGRQLAIIGDK(6-FAM)INR-amide probe binding to BCL-xl (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataKd:  10nMAssay Description:Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataKd:  7.80E+3nMAssay Description:Binding affinity to Bcl-w (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataKd: >2.00E+4nMAssay Description:Binding affinity to Mcl-1 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataIC50:  91nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50020930(CHEMBL3287293)
Affinity DataKd:  9.20E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed