BDBM50020938 CHEMBL3287301

SMILES OC(=O)c1nc(sc1CCCOc1ccccc1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1

InChI Key InChIKey=GMBBUSJVBYODHI-UHFFFAOYSA-N

Data  1 IC50  4 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50020938   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

LigandBDBM50020938(CHEMBL3287301)Copy SMILESCopy InChI

Affinity DataIC50:  1nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetBcl-2-like protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

LigandBDBM50020938(CHEMBL3287301)Copy SMILESCopy InChI

Affinity DataKd: <5nMAssay Description:Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Genentech

Curated by ChEMBL

LigandBDBM50020938(CHEMBL3287301)Copy SMILESCopy InChI

Affinity DataKd:  1.44E+4nMAssay Description:Binding affinity to Mcl-1 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetBcl-2-like protein 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL

LigandBDBM50020938(CHEMBL3287301)Copy SMILESCopy InChI

Affinity DataKd:  62nMAssay Description:Binding affinity to Bcl-w (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Genentech

Curated by ChEMBL

LigandBDBM50020938(CHEMBL3287301)Copy SMILESCopy InChI

Affinity DataKd:  4.40E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI