BDBM50022929 CHEMBL3298376

SMILES CN(C)CC[C@@H](c1cccc(Cl)c1)n1cc(NC(=O)c2n[nH]c3CC(C)(C)CCc23)cn1

InChI Key InChIKey=PGNRWZCKDIYZQF-NRFANRHFSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50022929   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50022929(CHEMBL3298376)
Affinity DataKi:  1.20nMAssay Description:Inhibition of GST-tagged full length ITK (unknown origin) using BLK peptide as substrate after 35 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50022929(CHEMBL3298376)
Affinity DataKi:  290nMAssay Description:Inhibition of human His-tagged full length AURKA using kemptide peptide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50022929(CHEMBL3298376)
Affinity DataIC50:  113nMAssay Description:Inhibition of ITK in human Jurkat cells assessed as reduction in PLC-gamma phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed