BDBM50026387 1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE::5-Benzyl-1-(2-hydroxy-ethoxymethyl)-1H-pyrimidine-2,4-dione::CHEMBL17432

SMILES OCCOCn1cc(Cc2ccccc2)c(=O)[nH]c1=O

InChI Key InChIKey=SPJAGILXQBHHSZ-UHFFFAOYSA-N

Data  1 IC50  4 Kd

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50026387   

TargetUridine phosphorylase 1(Mouse)
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50026387(1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4...)
Affinity DataIC50:  460nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUridine phosphorylase 1(Human)
Pontifical Catholic University of Rio Grande Do Sul

Curated by ChEMBL
LigandPNGBDBM50026387(1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4...)
Affinity DataKd:  6.60E+3nMAssay Description:Binding affinity to human recombinant UP1-R1P binary complex expressed in Escherichia coli Rosetta (DE3) at 150 uM R1P by isothermal titration calori...More data for this Ligand-Target Pair
TargetUridine phosphorylase 1(Human)
Pontifical Catholic University of Rio Grande Do Sul

Curated by ChEMBL
LigandPNGBDBM50026387(1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to human recombinant UP1 expressed in Escherichia coli Rosetta (DE3) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
TargetUridine phosphorylase 1(Human)
Pontifical Catholic University of Rio Grande Do Sul

Curated by ChEMBL
LigandPNGBDBM50026387(1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to human recombinant UP1-inorganic phosphate binary complex expressed in Escherichia coli Rosetta (DE3) by isothermal titration calo...More data for this Ligand-Target Pair
TargetUridine phosphorylase 1(Human)
Pontifical Catholic University of Rio Grande Do Sul

Curated by ChEMBL
LigandPNGBDBM50026387(1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to human recombinant UP1-R1P binary complex expressed in Escherichia coli Rosetta (DE3) at 50 uM R1P by isothermal titration calorim...More data for this Ligand-Target Pair