BDBM50027473 3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester::3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester(Lofentanil)::CHEMBL28198

SMILES CCC(=O)N(c1ccccc1)[C@]1(CCN(CCc2ccccc2)C[C@H]1C)C(=O)OC

InChI Key InChIKey=IMYHGORQCPYVBZ-NLFFAJNJSA-N

Data  3 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50027473   

TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50027473(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Affinity DataKi:  0.140nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor mu 1More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50027473(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Affinity DataKi:  5.5nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50027473(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Affinity DataKi:  24nMAssay Description:Competitive binding affinity against transfected HEK293 cells expressing Opioid receptor like 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027473(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Affinity DataIC50:  0.25nMAssay Description:Displacement of [3H]nalotrexone from rat-brain Opioid receptorsMore data for this Ligand-Target Pair