BDBM50028598 1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine::CHEMBL89970

SMILES CN1CCN(CC1)C1=Cc2ccccc2Oc2ccccc12

InChI Key InChIKey=ZCCUIFWJESTQQQ-UHFFFAOYSA-N

Data  9 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50028598   

TargetD(4) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  2nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  2nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D4 in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  4nMAssay Description:Affinity was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  4nMAssay Description:Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2A serotonin receptor in NIH3T3 cell line membr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  6nMAssay Description:Affinity of the compound was evaluated by inhibition of [125I]-LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2C recept...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  6nMAssay Description:Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2C serotonin receptor in NIH3T3 cell line membr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  21nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-2(long) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  21nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D2L in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataKi:  41nMAssay Description:Affinity was evaluated by inhibition of [3H]-GR-65,630 binding to NG108-15 cell transfected with cloned rat 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataIC50:  2.29E+3nMAssay Description:Tested in vitro for its ability to displace 3[H] clozapine from Muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50028598(1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine | C...)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of 3[H]spiroperidol from Dopamine receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed