BDBM50029774 4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2-ylethynyl)-benzoic acid::CHEMBL358145

SMILES Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C#Cc1ccc(cc1)C(O)=O

InChI Key InChIKey=NCEQLLNVRRTCKJ-UHFFFAOYSA-N

Data  3 IC50  9 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50029774   

TargetRetinoic acid receptor beta(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataKd:  2nMAssay Description:Binding constant for baculovirus-expressed Retinoic acid receptor RAR alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataKd:  3nMAssay Description:Binding constant for baculovirus-expressed Retinoic acid receptor RAR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataKd:  2nMAssay Description:Binding constant for baculovirus-expressed Retinoic acid receptor RAR betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataKd:  7nMAssay Description:Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataKd:  7nMAssay Description:Ability to inhibit TTNPB-induced transactivation at retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataKd:  16nMAssay Description:Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataIC50:  31nMAssay Description:Antagonist activity of TTNPB (10 nM) function at retinoic acid receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataKd:  6nMAssay Description:Binding affinity towards retinoic acid receptor gamma was determined using [3H]-ATRA (5 nM) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataIC50:  3nMAssay Description:Binding affinity towards retinoic acid receptor alpha was determined using [3H]-ATRA (5 nM) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataKd:  17nMAssay Description:Binding affinity towards retinoic acid receptor alpha was determined using [3H]-ATRA (5 nM) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50029774(4-(5,5-Dimethyl-8-p-tolyl-5,6-dihydro-naphthalen-2...)
Affinity DataKd:  7nMAssay Description:Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed