BDBM50030617 2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicarboxylic acid 3-amide 5-{[3-(4,4-diphenyl-piperidin-1-yl)-propyl]-amide}::CHEMBL122671

SMILES Cc1nc(C)c(C(=O)NCCCN2CCC(CC2)(c2ccccc2)c2ccccc2)c(-c2ccc(cc2)[N+]([O-])=O)c1C(N)=O

InChI Key InChIKey=XAFOTAKURAOBIE-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50030617   

TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030617(2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicar...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1A adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030617(2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicar...)
Affinity DataKi: >10nMAssay Description:Inhibition of [3H]nitrendipine binding to membrane homogenates of of rat cardiac muscle.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030617(2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicar...)
Affinity DataKi:  148nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030617(2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicar...)
Affinity DataKi:  165nMAssay Description:Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030617(2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicar...)
Affinity DataKi:  275nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030617(2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicar...)
Affinity DataKi:  346nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030617(2,6-Dimethyl-4-(4-nitro-phenyl)-pyridine-3,5-dicar...)
Affinity DataKi:  407nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1B adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed