BDBM50034443 8-Dimethylamino-naphthalene-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide::CHEMBL29705

SMILES CN(C)c1cccc2ccc(cc12)S(=O)(=O)Nc1onc(C)c1C

InChI Key InChIKey=CDAANMFWIWNGIT-UHFFFAOYSA-N

Data  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50034443   

TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034443(8-Dimethylamino-naphthalene-2-sulfonic acid (3,4-d...)
Show SMILES CN(C)c1cccc2ccc(cc12)S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C17H19N3O3S/c1-11-12(2)18-23-17(11)19-24(21,22)14-9-8-13-6-5-7-16(20(3)4)15(13)10-14/h5-10,19H,1-4H3
Affinity DataIC50: 3.15E+4nMAssay Description:Inhibition of [125I]-endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsMore data for this Ligand-Target Pair
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034443(8-Dimethylamino-naphthalene-2-sulfonic acid (3,4-d...)
Show SMILES CN(C)c1cccc2ccc(cc12)S(=O)(=O)Nc1onc(C)c1C
Show InChI InChI=1S/C17H19N3O3S/c1-11-12(2)18-23-17(11)19-24(21,22)14-9-8-13-6-5-7-16(20(3)4)15(13)10-14/h5-10,19H,1-4H3
Affinity DataIC50: 3.15E+4nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair