BDBM50034446 CHEMBL27065::Naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide

SMILES Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C

InChI Key InChIKey=ZEOXLCVRBAOHIV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50034446   

TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034446(CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...)
Affinity DataIC50:  2.00E+4nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034446(CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of [125I]-endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50034446(CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...)
Affinity DataIC50:  4.90E+4nMAssay Description:Binding affinity against human ETB receptor in transfected COS 7 cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50034446(CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...)
Affinity DataIC50:  440nMAssay Description:Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50034446(CHEMBL27065 | Naphthalene-1-sulfonic acid (3,4-dim...)
Affinity DataIC50:  2.00E+4nMAssay Description:Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed