BDBM50034452 4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulfonamide::CHEMBL453::Eryzole::Gantrisin::Pediazole::SULFISOXAZOLE::Sosol::Soxazole::Sulfafurazole::Sulfalar::Sulfisoxazol::Sulphafurazole::Sulsoxin

SMILES Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C

InChI Key InChIKey=NHUHCSRWZMLRLA-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50034452   

TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50:  780nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50:  800nMAssay Description:Inhibition of [125I]-endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50:  780nMAssay Description:Ability to inhibit [125I]-ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50:  9.00E+3nMAssay Description:Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50:  2.40E+4nMAssay Description:Binding affinity against human Endothelin B receptor in transfected COS 7 cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50:  850nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034452(4-Amino-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50:  780nMAssay Description:Inhibitory concentration against Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed