BDBM50034562 3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide::3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide(Temozolomide)::CCRG-81045::CHEMBL810::M&B-39831::M-39831::SCH-52365::TEMOZOLOMIDE::Temodar

SMILES Cn1nnc2c(ncn2c1=O)C(N)=O

InChI Key InChIKey=BPEGJWRSRHCHSN-UHFFFAOYSA-N

Data  4 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50034562   

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Maastricht University Medical Centre

Curated by ChEMBL
LigandPNGBDBM50034562(3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Maastricht University Medical Centre

Curated by ChEMBL
LigandPNGBDBM50034562(3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Maastricht University Medical Centre

Curated by ChEMBL
LigandPNGBDBM50034562(3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Maastricht University Medical Centre

Curated by ChEMBL
LigandPNGBDBM50034562(3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 9 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034562(3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034562(3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034562(3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50034562(3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Mcgill University/Royal Victoria Hospital

Curated by ChEMBL
LigandPNGBDBM50034562(3-Methyl-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed