BDBM50034936 5-Methyl-6-{[prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL49454

SMILES COc1cc(cc(OC)c1OC)N(CC#C)Cc1cnc2nc(N)nc(N)c2c1C

InChI Key InChIKey=HWTHGASACLWVQR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50034936   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034936(5-Methyl-6-{[prop-2-ynyl-(3,4,5-trimethoxy-phenyl)...)
Affinity DataIC50:  54nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034936(5-Methyl-6-{[prop-2-ynyl-(3,4,5-trimethoxy-phenyl)...)
Affinity DataIC50:  7.70nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034936(5-Methyl-6-{[prop-2-ynyl-(3,4,5-trimethoxy-phenyl)...)
Affinity DataIC50:  11.8nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034936(5-Methyl-6-{[prop-2-ynyl-(3,4,5-trimethoxy-phenyl)...)
Affinity DataIC50:  53.5nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034936(5-Methyl-6-{[prop-2-ynyl-(3,4,5-trimethoxy-phenyl)...)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50034936(5-Methyl-6-{[prop-2-ynyl-(3,4,5-trimethoxy-phenyl)...)
Affinity DataIC50:  11.8nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed