BDBM50038839 2-(4-bromo-2-fluorobenzyl)-1H,2'H,5'H-spiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'(2H)-tetrone::2-(4-bromo-2-fluorobenzyl)spiro[1,2,3,4-tetrahydroisoquinoline-4,3'-(tetrahydro-1'H-pyrrole)]-1,2',3,5'-tetraone::CHEMBL62685

SMILES Fc1cc(Br)ccc1CN1C(=O)c2ccccc2C2(CC(=O)NC2=O)C1=O

InChI Key InChIKey=KJPABNWHOUDAIW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50038839   

TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50038839(2-(4-bromo-2-fluorobenzyl)-1H,2'H,5'H-spiro[isoqui...)
Affinity DataIC50:  23nMAssay Description:Compound was tested in vitro for inhibition of aldose reductase activity in partially purified bovine lens preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50038839(2-(4-bromo-2-fluorobenzyl)-1H,2'H,5'H-spiro[isoqui...)
Affinity DataIC50:  19nMAssay Description:Compound was evaluated In vitro for inhibition of aldose reductase activity by 50% in dog RBCChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50038839(2-(4-bromo-2-fluorobenzyl)-1H,2'H,5'H-spiro[isoqui...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparationChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed