BDBM50042185 4,5-Bis-benzo[1,3]dioxol-5-ylmethyl-1-methyl-1H-imidazol-2-ylamine::CHEMBL111825::leucettamine A

SMILES Cn1c(N)nc(Cc2ccc3OCOc3c2)c1Cc1ccc2OCOc2c1

InChI Key InChIKey=CHUHMZZQHYOKBF-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50042185   

TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042185(4,5-Bis-benzo[1,3]dioxol-5-ylmethyl-1-methyl-1H-im...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042185(4,5-Bis-benzo[1,3]dioxol-5-ylmethyl-1-methyl-1H-im...)
Affinity DataKi:  3.50E+3nMAssay Description:Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]-LTB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042185(4,5-Bis-benzo[1,3]dioxol-5-ylmethyl-1-methyl-1H-im...)
Affinity DataIC50:  4.00E+3nMAssay Description:Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042185(4,5-Bis-benzo[1,3]dioxol-5-ylmethyl-1-methyl-1H-im...)
Affinity DataIC50:  4.60E+3nMAssay Description:Antagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50042185(4,5-Bis-benzo[1,3]dioxol-5-ylmethyl-1-methyl-1H-im...)
Affinity DataIC50:  750nMAssay Description:Binding affinity to LTB4 receptor in human U937 cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed