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BDBM50047884 4-Hydroxy-2-oxo-1-phenyl-1,2-dihydro-[1,8]naphthyridine-3-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide::CHEMBL156920

SMILES: CN1C2CCC1CC(C2)NC(=O)c1c(O)c2cccnc2n(-c2ccccc2)c1=O

InChI Key: InChIKey=PKZJCCXPAPHAET-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50047884   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50047884
PNG
(4-Hydroxy-2-oxo-1-phenyl-1,2-dihydro-[1,8]naphthyr...)
Show SMILES CN1C2CCC1CC(C2)NC(=O)c1c(O)c2cccnc2n(-c2ccccc2)c1=O
Show InChI InChI=1S/C23H24N4O3/c1-26-16-9-10-17(26)13-14(12-16)25-22(29)19-20(28)18-8-5-11-24-21(18)27(23(19)30)15-6-3-2-4-7-15/h2-8,11,14,16-17,28H,9-10,12-13H2,1H3,(H,25,29)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
14n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against radioligand [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in neuroblastoma-glioma (NG108-15) cells.


J Med Chem 36: 617-26 (1993)


Article DOI: 10.1021/jm00057a011
BindingDB Entry DOI: 10.7270/Q25B034N
More data for this
Ligand-Target Pair