BDBM50049205 CHEMBL48602::RWJ-46458::[4-Ethyl-4-methyl-6-oxo-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-piperidin-(2E)-ylidene]-acetic acid ethyl ester

SMILES CCOC(=O)\C=C1/CC(C)(CC)CC(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1

InChI Key InChIKey=JBEUFWOCGLXNCS-XSFVSMFZSA-N

Data  3 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50049205   

TargetType-1 angiotensin II receptor(RABBIT)
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM50049205(CHEMBL48602 | RWJ-46458 | [4-Ethyl-4-methyl-6-oxo-...)
Affinity DataKd:  1nMAssay Description:Antagonist activity at angiotensin AT1 receptor in rabbit aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM50049205(CHEMBL48602 | RWJ-46458 | [4-Ethyl-4-methyl-6-oxo-...)
Affinity DataKd:  2.5nMAssay Description:In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(RABBIT)
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM50049205(CHEMBL48602 | RWJ-46458 | [4-Ethyl-4-methyl-6-oxo-...)
Affinity DataKd:  2.51nMAssay Description:In vitro binding affinity against Angiotensin II receptor in rabbit aorta ringsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetType-1 angiotensin II receptor(Bos taurus)
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM50049205(CHEMBL48602 | RWJ-46458 | [4-Ethyl-4-methyl-6-oxo-...)
Affinity DataIC50:  250nMAssay Description:Binding affinity to angiotensin AT1 receptor in bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bos taurus)
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM50049205(CHEMBL48602 | RWJ-46458 | [4-Ethyl-4-methyl-6-oxo-...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in bovine adrenal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Bos taurus)
The M. S. University Of Baroda

Curated by ChEMBL
LigandPNGBDBM50049205(CHEMBL48602 | RWJ-46458 | [4-Ethyl-4-methyl-6-oxo-...)
Affinity DataIC50:  250nMAssay Description:Ability of the compound to displace [125I]- labelled [Sar1,Ileu8] from angiotensin II receptor of bovine adrenal cortex membranesMore data for this Ligand-Target Pair
In DepthDetails Article