BDBM50049243 5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazolidine-2,4-dione::5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazolidine-2,4-dione (ciglitazone)::5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazolidine-2,4-dione(Ciglitazone)::CHEMBL7002::CIGLITAZONE::US8637558, 112

SMILES CC1(COc2ccc(Cc3sc(=O)[nH]c3O)cc2)CCCCC1

InChI Key InChIKey=YNQLJZYIOAPXMU-UHFFFAOYSA-N

Data  1 KI  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50049243   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50049243(5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazoli...)
Affinity DataKi:  3.09E+3nMAssay Description:In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assa...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor gamma(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50049243(5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazoli...)
Affinity DataEC50:  2.29E+4nMAssay Description:Activation of peroxisome proliferator activated receptor gamma measured by induction of 50% of maximum alkaline phosphatase activity, transfection as...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase [flavin-containing] B(Human)
Northeastern Ohio Universities

Curated by ChEMBL
LigandPNGBDBM50049243(5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazoli...)
Affinity DataIC50:  225nMAssay Description:Inhibition of human recombinant MAO-B after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeroxisome proliferator-activated receptor gamma(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50049243(5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazoli...)
Affinity DataEC50:  1.49E+4nMAssay Description:Agonist activity at human PPARgamma expressed in mouse NIH/3T3 cells assessed as receptor activation after 16 hrs by luciferase based reporter gene a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50049243(5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazoli...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of PGDH (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50049243(5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazoli...)
Affinity DataIC50:  1.74E+3nMpH: 7.5Assay Description:Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50049243(5-[4-(1-Methyl-cyclohexylmethoxy)-benzyl]-thiazoli...)
Affinity DataEC50:  3.00E+3nMAssay Description:In vitro transcriptional activation of Peroxisome proliferator activated receptor gamma (PPAR) expressed in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed