BDBM50049400 (+/-) taxifolin::(+/-)-Dihydroquercetin::(+/-)-taxifolin::(2R,3R)-2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chroman-4-one::(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one::2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chroman-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one::3,5,7,3',4'-pentahydroxyflavanone::CHEMBL337309::NSC-2801

SMILES OC1C(=O)C(Oc2cc(O)cc(O)c12)c1ccc(O)c(O)c1

InChI Key InChIKey=BYVWXQRJRYELNP-UHFFFAOYSA-N

Data  7 KI  11 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50049400   

TargetCarbonic anhydrase 12(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataKi:  33nM ΔG°:  -10.2kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataKi:  493nM ΔG°:  -8.60kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataKi:  9.10E+3nM ΔG°:  -6.87kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/moleT: 2°CAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataKi:  3.39E+4nMAssay Description:Ability to displace [125I]-AB-MECA binding from adenosine A3 receptor.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataKi:  3.41E+4nMAssay Description:Displacement of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50:  5.75E+3nMAssay Description:Inhibition of human recombinant MMP12 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
Universit£

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50:  2.09E+4nMAssay Description:Binding affinity to rabbit muscular GPb by NMR binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Oryctolagus cuniculus (rabbit))
Universit£

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50:  4.80E+3nMAssay Description:Binding affinity to rabbit muscular GPa by NMR binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50:  3.39E+4nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50:  2.26E+4nMAssay Description:Inhibition of human recombinant MMP2 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50:  3.46E+4nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrease subunit beta(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Jishou University

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50:  4.37E+4nMAssay Description:Inhibition of Helicobacter pylori ATCC 43504 urease-mediated ammonia production preincubated for 1.5 hrs by indophenol methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataKd:  3.74E+4nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CD38 using 20 uM 1, N6-etheno NAD+ as substrate by continuous fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50049400((+/-) taxifolin | (+/-)-Dihydroquercetin | (+/-)-t...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed