BDBM50050383 6-[(4-Chloro-phenylamino)-methyl]-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL23492

SMILES Nc1nc(N)c2cc(CNc3ccc(Cl)cc3)cnc2n1

InChI Key InChIKey=LBAODZYBBOYEOK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50050383   

TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050383(6-[(4-Chloro-phenylamino)-methyl]-pyrido[2,3-d]pyr...)
Affinity DataIC50:  970nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050383(6-[(4-Chloro-phenylamino)-methyl]-pyrido[2,3-d]pyr...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050383(6-[(4-Chloro-phenylamino)-methyl]-pyrido[2,3-d]pyr...)
Affinity DataIC50:  73nMAssay Description:Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050383(6-[(4-Chloro-phenylamino)-methyl]-pyrido[2,3-d]pyr...)
Affinity DataIC50:  670nMAssay Description:Antimycobacterial activity against human dihydrofolate reductase (hDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050383(6-[(4-Chloro-phenylamino)-methyl]-pyrido[2,3-d]pyr...)
Affinity DataIC50:  720nMAssay Description:Inhibitory activity of the compound against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed