BDBM50050397 6-(4-Chloro-phenylsulfanylmethyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL22677::xv6-(4-Chloro-phenylsulfanylmethyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine

SMILES Cc1c(CSc2ccc(Cl)cc2)cnc2nc(N)nc(N)c12

InChI Key InChIKey=UXHWDAJRTNZWPO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50050397   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050397(6-(4-Chloro-phenylsulfanylmethyl)-5-methyl-pyrido[...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050397(6-(4-Chloro-phenylsulfanylmethyl)-5-methyl-pyrido[...)
Affinity DataIC50:  360nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050397(6-(4-Chloro-phenylsulfanylmethyl)-5-methyl-pyrido[...)
Affinity DataIC50:  3.60nMAssay Description:Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50050397(6-(4-Chloro-phenylsulfanylmethyl)-5-methyl-pyrido[...)
Affinity DataIC50:  590nMAssay Description:Antimycobacterial activity against human dihydrofolate reductase (hDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50050397(6-(4-Chloro-phenylsulfanylmethyl)-5-methyl-pyrido[...)
Affinity DataIC50:  370nMAssay Description:Inhibitory activity of the compound against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed