BDBM50051893 2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-imidazole::CHEMBL286812

SMILES CC1(C)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1

InChI Key InChIKey=GYFQLJRMPAKHQL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50051893   

TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051893(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051893(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Affinity DataIC50:  75nMAssay Description:In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051893(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA:cholesterol acyltransferase(Oryctolagus cuniculus)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50051893(2-(5,5-Dimethyl-[1,3]dioxan-2-yl)-4,5-diphenyl-1H-...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit artery Acyl coenzyme A:cholest...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed