BDBM50052881 AGN-192172::CHEMBL49284::Imidazolidin-2-ylidene-(5-methyl-1,2,3,4-tetrahydro-quinoxalin-6-yl)-amine

SMILES [#6]-c1c(ccc2-[#7]-[#6]-[#6]-[#7]-c12)\[#7]=[#6]-1/[#7]-[#6]-[#6]-[#7]-1

InChI Key InChIKey=PGOVKWAJCVAZNG-UHFFFAOYSA-N

Data  7 KI  1 EC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50052881   

TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50052881(AGN-192172 | CHEMBL49284 | Imidazolidin-2-ylidene-...)
Show SMILES Cc1c(ccc2NCCNc12)N=C1NCCN1
Show InChI InChI=1S/C12H17N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-3,13-14H,4-7H2,1H3,(H2,15,16,17)
Affinity DataKi:  6.80nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cellsMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Allergan Inc

Curated by ChEMBL
LigandPNGBDBM50052881(AGN-192172 | CHEMBL49284 | Imidazolidin-2-ylidene-...)
Show SMILES Cc1c(ccc2NCCNc12)N=C1NCCN1
Show InChI InChI=1S/C12H17N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-3,13-14H,4-7H2,1H3,(H2,15,16,17)
Affinity DataKi:  9.60nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamst...More data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50052881(AGN-192172 | CHEMBL49284 | Imidazolidin-2-ylidene-...)
Show SMILES Cc1c(ccc2NCCNc12)N=C1NCCN1
Show InChI InChI=1S/C12H17N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-3,13-14H,4-7H2,1H3,(H2,15,16,17)
Affinity DataKi:  9.60nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Allergan Inc

Curated by ChEMBL
LigandPNGBDBM50052881(AGN-192172 | CHEMBL49284 | Imidazolidin-2-ylidene-...)
Show SMILES Cc1c(ccc2NCCNc12)N=C1NCCN1
Show InChI InChI=1S/C12H17N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-3,13-14H,4-7H2,1H3,(H2,15,16,17)
Affinity DataKi:  120nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamste...More data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(NEONATAL RAT)
Allergan Inc

Curated by ChEMBL
LigandPNGBDBM50052881(AGN-192172 | CHEMBL49284 | Imidazolidin-2-ylidene-...)
Show SMILES Cc1c(ccc2NCCNc12)N=C1NCCN1
Show InChI InChI=1S/C12H17N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-3,13-14H,4-7H2,1H3,(H2,15,16,17)
Affinity DataKi:  140nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ...More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50052881(AGN-192172 | CHEMBL49284 | Imidazolidin-2-ylidene-...)
Show SMILES Cc1c(ccc2NCCNc12)N=C1NCCN1
Show InChI InChI=1S/C12H17N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-3,13-14H,4-7H2,1H3,(H2,15,16,17)
Affinity DataKi:  8.70E+3nMAssay Description:Binding affinity towards Alpha-1 adrenergic receptor in human brainMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50052881(AGN-192172 | CHEMBL49284 | Imidazolidin-2-ylidene-...)
Show SMILES Cc1c(ccc2NCCNc12)N=C1NCCN1
Show InChI InChI=1S/C12H17N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-3,13-14H,4-7H2,1H3,(H2,15,16,17)
Affinity DataKi:  8.90E+3nMAssay Description:Binding affinity for Alpha-1 adrenergic receptor of human cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50052881(AGN-192172 | CHEMBL49284 | Imidazolidin-2-ylidene-...)
Show SMILES Cc1c(ccc2NCCNc12)N=C1NCCN1
Show InChI InChI=1S/C12H17N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-3,13-14H,4-7H2,1H3,(H2,15,16,17)
Affinity DataEC50:  3.5nMAssay Description:Inhibition of Alpha-2 adrenergic receptor induced contractile response of rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails