BDBM50053629 2-Chloro-Phenyl biguanide::CHEMBL42752::N-(2-chlorophenyl)imidodicarbonimidic diamide

SMILES NC(=N)N=C(N)Nc1ccccc1Cl

InChI Key InChIKey=MKWFJPZMYHPQIA-UHFFFAOYSA-N

Data  1 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50053629   

Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50053629(2-Chloro-Phenyl biguanide | CHEMBL42752 | N-(2-chl...)
Affinity DataKi:  62nMAssay Description:Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
University Of Genoa

Curated by ChEMBL
LigandPNGBDBM50053629(2-Chloro-Phenyl biguanide | CHEMBL42752 | N-(2-chl...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
University Of Genoa

Curated by ChEMBL
LigandPNGBDBM50053629(2-Chloro-Phenyl biguanide | CHEMBL42752 | N-(2-chl...)
Affinity DataEC50:  410nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Chinese Academy Of Medical Sciences And Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50053629(2-Chloro-Phenyl biguanide | CHEMBL42752 | N-(2-chl...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of integrin alphavbeta3 mediated cell adhesion of human M21 cells to vitronectiinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrace amine-associated receptor 5(Mus musculus)
University Of Genoa

Curated by ChEMBL
LigandPNGBDBM50053629(2-Chloro-Phenyl biguanide | CHEMBL42752 | N-(2-chl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed