BDBM50054143 (+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione::(+/-) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione::(-) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione::8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione::CHEMBL11265

SMILES COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12

InChI Key InChIKey=XVCOCVUIJOUBOY-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50054143   

TargetD(2) dopamine receptor(BOVINE)
Université

Curated by ChEMBL
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  1.31E+4nMAssay Description:Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Université

Curated by ChEMBL
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  3.80E+3nMAssay Description:Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(BOVINE)
Université

Curated by ChEMBL
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  2.24E+4nMAssay Description:Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Université

Curated by ChEMBL
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  10.6nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
Université

Curated by ChEMBL
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  1.31E+4nMAssay Description:Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(BOVINE)
Université

Curated by ChEMBL
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  2.33E+4nMAssay Description:Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of platelet glycoprotein alpha IIb beta3 integrin in ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Université

Curated by ChEMBL
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  6.72nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  11nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor by displacement of [3H]8-OH-DPAT.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))TBA
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  6.61E+3nMAssay Description:Compound was evaluated for the binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]ketanserin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  1.10E+3nMAssay Description:Compound was evaluated for the binding affinity towards Dopamine receptor D2 by displacement of [3H]SCH-23390.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))TBA
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  1.05E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2C receptor by displacement of [3H]N-methyl-mesulergineMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))TBA
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  3.80E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1B receptor by displacement of [3H]5-HT.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Université

Curated by ChEMBL
LigandPNGBDBM50054143((+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3...)
Affinity DataIC50:  1.30E+3nMAssay Description:Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed