BDBM50054149 1'-[4-(4-fluorophenylcarboxamido)butyl]-5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(hexahydropyridine)]::CHEMBL334498

SMILES COc1cccc2OCC3(CCCCN3CCCCNC(=O)c3ccc(F)cc3)Cc12

InChI Key InChIKey=ZEVJZQFRPPUZBU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50054149   

Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Université

Curated by ChEMBL
LigandPNGBDBM50054149(1'-[4-(4-fluorophenylcarboxamido)butyl]-5-methoxys...)
Affinity DataIC50:  1.12E+4nMAssay Description:Compound was evaluated for binding affinity on 5-HT1B receptors using rat cortex+striatum+ globus pallidus,[ 3H]-5-OH-tryptamine, and serotonin for N...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(BOVINE)
Université

Curated by ChEMBL
LigandPNGBDBM50054149(1'-[4-(4-fluorophenylcarboxamido)butyl]-5-methoxys...)
Affinity DataIC50:  3.83E+4nMAssay Description:Displacement of [3H]-raclopride from Dopamine receptor D1 of calf striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
Université

Curated by ChEMBL
LigandPNGBDBM50054149(1'-[4-(4-fluorophenylcarboxamido)butyl]-5-methoxys...)
Affinity DataIC50:  4.30E+3nMAssay Description:Displacement of [3H]-SDZ-205-501 from Dopamine receptor D2 in calf caudate nucleus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Université

Curated by ChEMBL
LigandPNGBDBM50054149(1'-[4-(4-fluorophenylcarboxamido)butyl]-5-methoxys...)
Affinity DataIC50:  62.8nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in rat hippocampus membranes,3H-8-OH-DPAT and buspirone for nonspecific binding (NSB)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed