BDBM50056506 CHEMBL3341943::US10688093, Compound 382_0087_6488::US11701353, Compound 382_0087_6488

SMILES COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1cccc(NS(C)(=O)=O)c1

InChI Key InChIKey=ZPKLGSLFCKFOCY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50056506   

TargetActivin receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50056506(CHEMBL3341943 | US10688093, Compound 382_0087_6488...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50056506(CHEMBL3341943 | US10688093, Compound 382_0087_6488...)
Affinity DataIC50:  180nMAssay Description:Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50056506(CHEMBL3341943 | US10688093, Compound 382_0087_6488...)
Affinity DataIC50:  260nMAssay Description:Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Pathways Neuro Pharma

US Patent
LigandPNGBDBM50056506(CHEMBL3341943 | US10688093, Compound 382_0087_6488...)
Affinity DataIC50:  562nMAssay Description:The ADP-Glo™ Kinase Assay is specifically designed to quantify kinase activity by measuring the ADP produced in the reaction The reaction buffer...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Pathways Neuro Pharma

US Patent
LigandPNGBDBM50056506(CHEMBL3341943 | US10688093, Compound 382_0087_6488...)
Affinity DataIC50:  525nMAssay Description:The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Pathways Neuro Pharma

US Patent
LigandPNGBDBM50056506(CHEMBL3341943 | US10688093, Compound 382_0087_6488...)
Affinity DataIC50:  562nMAssay Description:The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Pathways Neuro Pharma

US Patent
LigandPNGBDBM50056506(CHEMBL3341943 | US10688093, Compound 382_0087_6488...)
Affinity DataIC50:  525nMAssay Description:The ADP-Glo™ Kinase Assay is specifically designed to quantify kinase activity by measuring the ADP produced in the reaction The reaction buffer...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Mus musculus)
Massachusetts Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50056506(CHEMBL3341943 | US10688093, Compound 382_0087_6488...)
Affinity DataIC50:  60nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed