BDBM500574 7-[[5-[(3R)-3- (1-hydroxy-1- methyl-ethyl)- 1-piperidyl)-2- pyridyl)- amino]-4-(7- methylimidazo [1,2-a]pyrimidin-3- yl]isoindolin- 1-one::US11021481, Compound I-233::US11078201, Compound I-233::US11548890, Compound I-233

SMILES Cc1ccn2c(cnc2n1)-c1ccc(Nc2ccc(cn2)N2CCC[C@H](C2)C(C)(C)O)c2C(=O)NCc12

InChI Key InChIKey=VYWIVSDGTCPHTD-GOSISDBHSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500574   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500574(7-[[5-[(3R)-3- (1-hydroxy-1- methyl-ethyl)- 1-pipe...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500574(7-[[5-[(3R)-3- (1-hydroxy-1- methyl-ethyl)- 1-pipe...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500574(7-[[5-[(3R)-3- (1-hydroxy-1- methyl-ethyl)- 1-pipe...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500574(7-[[5-[(3R)-3- (1-hydroxy-1- methyl-ethyl)- 1-pipe...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500574(7-[[5-[(3R)-3- (1-hydroxy-1- methyl-ethyl)- 1-pipe...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent