BDBM50058464 2-Ethyl-1-(4-trifluoromethyl-phenyl)-isothiourea; hydrochloride::CHEMBL323542::CHEMBL542855

SMILES CCSC(N)=Nc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=LCMOXIFARISMOH-UHFFFAOYSA-N

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50058464   

TargetNitric oxide synthase, brain(Human)
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50058464(2-Ethyl-1-(4-trifluoromethyl-phenyl)-isothiourea; ...)
Affinity DataKi:  320nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Human)
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50058464(2-Ethyl-1-(4-trifluoromethyl-phenyl)-isothiourea; ...)
Affinity DataKi:  320nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058464(2-Ethyl-1-(4-trifluoromethyl-phenyl)-isothiourea; ...)
Affinity DataKi:  9.40E+3nMAssay Description:Inhibitory activity against human vascular endothelial nitric oxide synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Human)
Glaxo Wellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50058464(2-Ethyl-1-(4-trifluoromethyl-phenyl)-isothiourea; ...)
Affinity DataKi:  3.70E+4nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed