BDBM50060728 (R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hydroxybenzyl)pentanamide::(R)-2-Diphenylacetylamino-5-guanidino-pentanoic acid 4-hydroxy-benzylamide::(R)-5-(diaminomethyleneamino)-2-(2,2-diphenylacetamido)-N-(4-hydroxybenzyl)pentanamide::CHEMBL332347

SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6](-c1ccccc1)-c1ccccc1)-[#6](=O)-[#7]-[#6]-c1ccc(-[#8])cc1

InChI Key InChIKey=KUWBXRGRMQZCSS-HSZRJFAPSA-N

Data  20 KI  5 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50060728   

TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  1nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  1.30nMAssay Description:Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  5.10nMAssay Description:Displacement of radiolabled NPY from human Y1R expressed in human SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  12nMAssay Description:Binding affinity to human NPFF1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  15nMAssay Description:Inhibition of binding of [125I]-PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]NPVF from human NPFF1 expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 2(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  84nMAssay Description:Binding affinity to human NPFF2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 2(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]EYF from human NPFF2 expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi:  2.32E+3nMAssay Description:Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 4(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to human neuropeptide Y receptor type 4 receptor expressed in CHO cells using Cy5-[K4]-hPP by flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi: >1.00E+4nMAssay Description:Affinity for human Neuropeptide Y receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 4(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi: >1.00E+4nMAssay Description:Affinity for human Neuropeptide Y receptor type 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKi: >1.00E+4nMAssay Description:Affinity for human Neuropeptide Y receptor type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataIC50:  4nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 2(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataEC50:  233nMAssay Description:Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide FF receptor 1(Homo sapiens (Human))
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50060728((R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-hyd...)
Affinity DataKd:  20.9nMAssay Description:Competitive antagonist activity at human NPFF1 receptor expressed in COS1 cells assessed as inhibition of NPVF-induced [3H]inositol phosphate accumul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed