BDBM50061061 (4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline-2-carboxylic acid diethylamide::CHEMBL100729

SMILES CCN(CC)C(=O)c1[nH]c2C[C@]3(CCN(CC)C[C@@H]3Cc2c1C)c1cccc(O)c1

InChI Key InChIKey=LCXJNOQXEGZLDX-UQBPGWFLSA-N

Data  14 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50061061   

TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  0.950nMAssay Description:inhibition of [3H]DADLE binding to delta-opioid receptor of mouse brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  1.90nMAssay Description:inhibition of [3H]DADLE binding to delta-opioid receptor of mouse brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  1.90nMAssay Description:inhibition of [3H]DADLE binding to delta-opioid receptor of mouse brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  407nMAssay Description:Inhibition of [3H]DAMGO from mouse brain homogenate Mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  407nMAssay Description:Inhibition of [3H]DAMGO from mouse brain homogenate Mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  407nMAssay Description:Binding affinity against Opioid receptor mu 1 using [3H][D-Ala2, MePhe4, Gly-ol5]-enkephalin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of [3H]DAMGO from mouse brain homogenate Mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  1.34E+3nMAssay Description:Binding affinity against Kappa opioid receptor using [3H]U-69593 radioligand in mouse brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  1.34E+3nMAssay Description:Binding affinity against Kappa opioid receptor using [3H]U-69593 radioligand in mouse brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  3.53E+3nMAssay Description:Binding affinity against Opioid receptor delta 1 using [3H][D-Ala2, D-Leu5]-enkephalin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi: >5.00E+3nMAssay Description:inhibition of [3H]DADLE binding to delta-opioid receptor of mouse brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity against Opioid receptor mu 1 using [3H][D-Ala2, MePhe4, Gly-ol5]-enkephalin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  6.00E+3nMAssay Description:Binding affinity against Opioid receptor kappa 1 using [3H]-U-69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  6.01E+3nMAssay Description:Binding affinity against Opioid receptor kappa 1 using [3H]-U-69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataIC50:  34nMAssay Description:In vitro agonist activity for Opioid receptor delta 1 was determined in a mouse vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataIC50:  330nMAssay Description:In vitro antagonist activity against Opioid receptor delta 1 in the presence of 30 nM naltrindole, in a mouse vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataIC50:  462nMAssay Description:Inv itro antagonist activity against Opioid receptor delta 1 in the presence of 30 nM naltrindole, in a mouse vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed