BDBM50062261 CHEMBL829::Dimethyl-(2-methyl-3-phenothiazin-10-yl-propyl)-amine::Methylpromazine::N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine::TRIMEPRAZINE::Temaril

SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12

InChI Key InChIKey=ZZHLYYDVIOPZBE-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 Kd

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50062261   

TargetHistamine H1 receptor(RAT)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50062261(CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...)
Show SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50062261(CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...)
Show SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
Affinity DataKi:  1.27E+5nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50062261(CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...)
Show SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
Affinity DataIC50: 7.37E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
TargetAlbumin(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50062261(CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...)
Show SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
Affinity DataKd:  2.04E+4nMAssay Description:Binding affinity to bovine serum albumin by circular dichroic probe techniqueMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50062261(CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...)
Show SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
Affinity DataIC50: 2.49E+5nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductaseMore data for this Ligand-Target Pair