BDBM50062599 3,5-Dimethyl-adamantan-1-ylamine::CHEMBL807::EN300-123026::MEMANTINE::Namenda::US10214478, Compound memantine

SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2

InChI Key InChIKey=BUGYDGFZZOZRHP-UHFFFAOYSA-N

Data  12 KI  19 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50062599   

LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  433nMMore data for this Ligand-Target Pair
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  690nMMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  700nMAssay Description:Compound with the N-methyl-D-aspartate glutamate receptor blocking activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  700nMMore data for this Ligand-Target Pair
TargetIonotropic glutamate receptor subunit Delta2(Xenopus)
State University Of New York

Curated by PDSP Ki Database
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of recombinant GluN1/GluN2B receptor (unknown origin) expressed in HEK293 cells by patch-clamp methodMore data for this Ligand-Target Pair
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  1.32E+3nMMore data for this Ligand-Target Pair
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  1.37E+3nMMore data for this Ligand-Target Pair
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  1.73E+3nMMore data for this Ligand-Target Pair
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  1.78E+3nMMore data for this Ligand-Target Pair
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi:  2.42E+3nMMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]Ifenprodil from NMDAR-2B in Sprague-Dawley rat frontal cortex homogenates after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assess...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of dexamethasone-induced human NR1-1a/NR2B receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L13-E6 cells assesse...More data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Friedrich-Schiller-Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of equine serum BChE by modified Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of eGFP-tagged rat GluN1-1a/GluN2A transfected in human tsA201 cells assessed as inhibition glutamate-induced current measured at -65 mV h...More data for this Ligand-Target Pair
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  2.72E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  9.52E+3nMAssay Description:Inhibition of NMDA NR1/NR2B receptor (unknown origin) expressed in xenopus oocytes assessed as inhibition of NMDA and glycine-induced current respons...More data for this Ligand-Target Pair
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataEC50:  2.72E+3nMAssay Description:Isolated primary cerebellum granule cells of infant rats were inoculated in 96-well plates with 1.2×105/well by using 10% FBS+25 mM KCl+2 mM Glutamin...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Rattus norvegicus (Rat))
Hiroshima University

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  2.10E+3nMAssay Description:Antagonist activity at rat brain GluN1/GluN2B receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced channe...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  1.38E+3nMAssay Description:Antagonist activity at rat brain GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced channe...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  4.36E+3nMpH: 7.6Assay Description:Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced cur...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  0.950nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University Of Barcelona

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  1.02E+3nMAssay Description:Antagonist activity at recombinant NR1/NR2B receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  911nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  2.30E+3nMAssay Description:Antagonist activity at GluN1a/GluN2A (unknown origin) expressed in Xenopus laevis oocytes at -60 mV holding potential by voltage clamp methodMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Friedrich-Schiller-Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of human GluN1-1a/NR2A receptor expressed in transgenic mouse fibroblast cells assessed as inhibition of L-glutamate-induced excitotoxicit...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rattus norvegicus (Rat))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human GluN1-1a/NR2B receptor expressed in transgenic mouse fibroblast cells assessed as inhibition of L-glutamate-induced excitotoxicit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  1.58E+3nMAssay Description:IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Friedrich-Schiller-Universitat Jena

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of electric eel AChE by modified Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed