BDBM50064339 (9S,12R,13S)-12-Isobutyl-3,11-dioxo-1-oxa-4,10-diaza-cyclotridecane-9,13-dicarboxylic acid 13-hydroxyamide 9-methylamide::12-Isobutyl-3,11-dioxo-1-oxa-4,10-diaza-cyclotridecane-9,13-dicarboxylic acid 13-hydroxyamide 9-methylamide (SC903)::CHEMBL48258

SMILES CNC(=O)[C@@H]1CCCCNC(=O)CO[C@@H]([C@@H](CC(C)C)C(=O)N1)C(=O)NO

InChI Key InChIKey=PGWQPFWCLKSUIC-DYEKYZERSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50064339   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064339((9S,12R,13S)-12-Isobutyl-3,11-dioxo-1-oxa-4,10-dia...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of MMP-9 (Matrix metalloproteinase-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064339((9S,12R,13S)-12-Isobutyl-3,11-dioxo-1-oxa-4,10-dia...)
Affinity DataKi:  2.60nMAssay Description:In vitro inhibition of human MMP-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064339((9S,12R,13S)-12-Isobutyl-3,11-dioxo-1-oxa-4,10-dia...)
Affinity DataKi:  2.80nMAssay Description:In vitro inhibition of human MMP-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064339((9S,12R,13S)-12-Isobutyl-3,11-dioxo-1-oxa-4,10-dia...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of MMP-1 (Matrix metalloproteinase-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064339((9S,12R,13S)-12-Isobutyl-3,11-dioxo-1-oxa-4,10-dia...)
Affinity DataKi:  24nMAssay Description:Inhibition of human MMP-3.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064339((9S,12R,13S)-12-Isobutyl-3,11-dioxo-1-oxa-4,10-dia...)
Affinity DataKi:  24.1nMAssay Description:Inhibition of MMP-3 (Matrix metalloproteinase-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50064339((9S,12R,13S)-12-Isobutyl-3,11-dioxo-1-oxa-4,10-dia...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of LPS-stimulated TNF-alpha release in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed