BDBM50068742 4'-Isobutyl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide::CHEMBL105490

SMILES CC(C)Cc1ccc(cc1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C

InChI Key InChIKey=BWTQPWDURQZRKQ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50068742   

TargetEndothelin-1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068742(4'-Isobutyl-biphenyl-2-sulfonic acid (3,4-dimethyl...)
Affinity DataKi:  18nMAssay Description:Inhibition of Human Endothelin A receptor expressed in CHO Cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068742(4'-Isobutyl-biphenyl-2-sulfonic acid (3,4-dimethyl...)
Affinity DataKi:  18nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068742(4'-Isobutyl-biphenyl-2-sulfonic acid (3,4-dimethyl...)
Affinity DataKi:  1.70E+3nMAssay Description:Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068742(4'-Isobutyl-biphenyl-2-sulfonic acid (3,4-dimethyl...)
Affinity DataKi:  1.70E+3nMAssay Description:Inihibition of Human Endothelin B receptor expressed in CHO Cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed