BDBM50069762 CHEMBL3182437::ML323::US9802904, 87
SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-n2ccnn2)n1
InChI Key InChIKey=VUIRVWPJNKZOSS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50069762
Affinity DataIC50: >1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
Affinity DataIC50: >1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
Affinity DataIC50: >1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of USP1 (unknown origin) by Ub-Rho110 assayMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48(Homo sapiens (Human))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
US Patent
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
US Patent
Affinity DataIC50: 76nMAssay Description:This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...More data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataEC50: 3.00E+3nMAssay Description:Inhibition of human USP1/UAF1 in human H1299 cells assessed as reduction in colony formation after 7 daysMore data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetWD repeat-containing protein 48(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human USP1/UAF1 using Ub-AMC substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48(Homo sapiens (Human))
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
US Patent
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
US Patent
Affinity DataIC50: 17nMAssay Description:This example demonstrates reversible inhibition of USP1/UAF1 by an embodiment of the invention.The compound (81) at a concentration of ten times its ...More data for this Ligand-Target Pair