BDBM50073566 1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-2-(2,6-dimethoxy-phenoxy)-ethanone::CHEMBL335731

SMILES COc1cccc(OC)c1OCC(=O)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1

InChI Key InChIKey=TVKDDIPFFFMLKI-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50073566   

TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073566(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataKi:  9.05nMAssay Description:The binding affinity of the compound was determined towards Alpha-1B adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073566(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataKi:  23.7nMAssay Description:The binding affinity of the compound was determined towards Alpha-1C adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073566(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataKi:  36.2nMAssay Description:The binding affinity of the compound was determined towards Alpha-1A adrenergic receptor in the COS cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073566(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration against Dopamine receptor D2 (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073566(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 1A receptor (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Recordati

Curated by ChEMBL
LigandPNGBDBM50073566(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 2A receptor (Inactive at >1000 nM concentration)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed