BDBM50075100 CHEMBL3414625
SMILES Cc1nc2c(s1)C(=O)C\C(=N/c1ccc(C)cc1)C2=O
InChI Key InChIKey=CANBMWXJDLUDFF-GZTJUZNOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50075100
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataEC50: <1.00E+3nMAssay Description:Inhibition of SETD8 in HEK293T cells assessed as reduction in H4K20me level after 2 to 3 days by Western blot analysisMore data for this Ligand-Target Pair