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BDBM50076137 (S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-biphenyl-2-carbonyl}-amino)-4-methyl-pentanoic acid::CHEMBL285129

SMILES: CC(C)C[C@H](NC(=O)c1c(NCc2cnc[nH]2)cccc1-c1ccccc1)C(O)=O

InChI Key: InChIKey=UVIFZTCJDBHNKJ-FQEVSTJZSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50076137   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50076137
PNG
((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Show SMILES CC(C)C[C@H](NC(=O)c1c(NCc2cnc[nH]2)cccc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C23H26N4O3/c1-15(2)11-20(23(29)30)27-22(28)21-18(16-7-4-3-5-8-16)9-6-10-19(21)25-13-17-12-24-14-26-17/h3-10,12,14-15,20,25H,11,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t20-/m0/s1
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 6.10E+3n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-GGPP incorporation into H-Ras-CVLL by Geranylgeranyl transferase type I


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B


(Homo sapiens (Human))
BDBM50076137
PNG
((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Show SMILES CC(C)C[C@H](NC(=O)c1c(NCc2cnc[nH]2)cccc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C23H26N4O3/c1-15(2)11-20(23(29)30)27-22(28)21-18(16-7-4-3-5-8-16)9-6-10-19(21)25-13-17-12-24-14-26-17/h3-10,12,14-15,20,25H,11,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t20-/m0/s1
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antibodypedia
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PC sid
UniChem

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Article
PubMed
n/an/a 4.60E+4n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]-FPP incorporation into H-Ras-CVLS by Farnesyl transferase


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Mus musculus)
BDBM50076137
PNG
((S)-2-({3-[(1H-Imidazol-4-ylmethyl)-amino]-bipheny...)
Show SMILES CC(C)C[C@H](NC(=O)c1c(NCc2cnc[nH]2)cccc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C23H26N4O3/c1-15(2)11-20(23(29)30)27-22(28)21-18(16-7-4-3-5-8-16)9-6-10-19(21)25-13-17-12-24-14-26-17/h3-10,12,14-15,20,25H,11,13H2,1-2H3,(H,24,26)(H,27,28)(H,29,30)/t20-/m0/s1
PDB

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KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
In vivo for inhibition of farnesylation based on the inhibition of H-Ras processing.


J Med Chem 42: 1333-40 (1999)


Article DOI: 10.1021/jm9900873
BindingDB Entry DOI: 10.7270/Q28G8JW7
More data for this
Ligand-Target Pair