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BDBM50076665 CHEMBL366423::N-{1-methyl-3-[1-(4-methoxyphenyl)-5-(4-chlorophenyl)-1H-pyrazol-3-yl]prop-2-ynyl}-N-hydroxy-N'-propylurea

SMILES: CCCNC(=O)N(O)C(C)C#Cc1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(OC)cc1

InChI Key: InChIKey=JXEOEDBENBQXNY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50076665   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50076665
PNG
(CHEMBL366423 | N-{1-methyl-3-[1-(4-methoxyphenyl)-...)
Show SMILES CCCNC(=O)N(O)C(C)C#Cc1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C24H25ClN4O3/c1-4-15-26-24(30)29(31)17(2)5-10-20-16-23(18-6-8-19(25)9-7-18)28(27-20)21-11-13-22(32-3)14-12-21/h6-9,11-14,16-17,31H,4,15H2,1-3H3,(H,26,30)
PDB
MMDB

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Similars

Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (5-LO) in intact rat barophilic leukemia cells (RBL-1)


Bioorg Med Chem Lett 9: 979-84 (1999)


Article DOI: 10.1016/s0960-894x(99)00117-1
BindingDB Entry DOI: 10.7270/Q2Z31XV3
More data for this
Ligand-Target Pair