BDBM50076744 CHEMBL3416733

SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O

InChI Key

Data  23 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50076744   

TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant ERAP2 expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-arginyl-7-amido-4-methyl coumarin as s...More data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human ERAP2 using R-AMC as substrate incubated for 5 to 10 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant ERAP1 expressed in baculovirus infected Sf9 cells using L-leucine-7-amido-4-methyl coumarin as substrate after 5 to 1...More data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human ERAP1 using L-AMC as substrate measured for 15 to 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human ERAP2 using R-AMC as substrate measured for 15 to 30 mins by microplate fluorescence reader methodMore data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant ERAP2 (unknown origin) expressed in baculovirus infected insect cells using L-arginine-7-amido-4-methylcoumarine as substra...More data for this Ligand-Target Pair
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 57nMAssay Description:Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assayMore data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 48nMAssay Description:Inhibition of ERAP1 (unknown origin) expressed in Hi5 cells by in vitro fluorimetric assayMore data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 80nMAssay Description:Inhibition of ERAP2 (unknown origin) expressed in Hi5 cells by in vitro fluorimetric assayMore data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant ERAP1 using L-leucine 7-amido-4-methyl coumarin as substrate after 5 to 10 mins by fluorescence microplate reader met...More data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant ERAP1 using L-leucine 7-amido-4-methyl coumarin as substrate after 5 to 10 mins by fluorescence microplate reader met...More data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 7.55E+5nMAssay Description:Inhibition of human ERAP2More data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human ERAP1More data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 52nMAssay Description:Inhibition of wild type ERAP1 (unknown origin) using L-Rho-Succ-FKARKF as substrate preincubated for 15 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 1nMAssay Description:Inhibition of APN (unknown origin) using Ala-AMC as substrateMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 3.60nMAssay Description:Inhibition of APN (unknown origin) using A-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAminopeptidase N(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 3.70nMAssay Description:Inhibition of APN (unknown origin) using A-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 186nMAssay Description:Inhibition of ERAP1 (unknown origin) using L-AMC as substrateMore data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 190nMAssay Description:Inhibition of ERAP1 (unknown origin) using L-AMC as substrateMore data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of ERAP2 (unknown origin) using R-AMC as substrateMore data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 2(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of ERAP2 (unknown origin) using R-AMC as substrateMore data for this Ligand-Target Pair
TargetEndoplasmic reticulum aminopeptidase 1(Homo sapiens (Human))
National Center for Scientific Research"Demokritos"

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human ERAP1 using L-AMC as substrate incubated for 5 to 10 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetLeucyl-cystinyl aminopeptidase(Homo sapiens (Human))
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandPNGBDBM50076744(CHEMBL3416733)
Show SMILES CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant IRAP expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-leucine-7-amido-4-methyl coumarin as su...More data for this Ligand-Target Pair